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Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

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Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure (e.g., iridectomy), if they are susceptible [see Warnings and Precautions (5.9)]

Small molecule agonists bind to a more tightly packed orthosteric pocket with distinct ECL3 and TM7 positioning compared to peptides, yet converge on similar mechanisms to induce the critical TM6 conformational change