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The plan is to offer patients a "long-term extension period" for their trials, giving whoever receives the placebo a chance to then switch and take the experimental drug
The review reframes GLP-1 biology within a unified neuro-ophthalmic circuit-positioning the retina and optic nerve as CNS extensions and focusing on glial biology, neuroinflammation, mitochondrial health, and blood-retinal/brain barrier integrity
The heat map for pain intensity is shown in Supplementary Figure S12
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