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Pigmentation typically develops progressively over time , reflecting downstream melanocyte signaling rather than an immediate effect
VPAC2 receptor is mainly distributed in the smooth muscle layer and the base of mucosal epithelium in lung
It is derived from a larger protein called BPC (Body Protection Compound) that naturally occurs in human gastric fluid, where it functions to maintain mucosal integrity and promote gastrointestinal homeostasis
People with GI conditions (such as chronic diarrhea, celiac disease, Crohn's disease, and ulcerative colitis) or who have had procedures like gastric bypass surgery that impair nutrient absorption are also at greater risk
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