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Those at a higher risk for developing a deficiency in Vitamin B12 levels include older adults, people with pernicious anemia, people with low stomach acid, people with malabsorption problems due to digestive problems such as IBS, gastritis, Colitis and Crohns (Ref) and certain medications

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But the FDA's briefing documents flagged it as an uncharacterized risk requiring further investigation before any approval, and researchers continue to weigh the angiogenic mechanism against the compound's apparent safety profile in animal models

Jia HM, Huang LF, Zheng Y, Li WX (2017) Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis