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Ortolani O, et al

3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

Shareholders claim the company made it sound like everyone would be pushed to the maximum, which would have made the drug look more powerful and easier to tolerate

In light of these data, we suggest therapies that target energy metabolism and ROS generation to improve kidney function recovery may need to also target the energy and redox derangements observed in the liver