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Check your timeline against the dose schedule First, where are you in the dose escalation

The decision to terminate the clinical development of Lotiglipron was based on the pharmacokinetic data from the clinical Phase 1 drug-drug interaction studies (NCT05671653 and NCT05788328), as well as the laboratory measurements of elevated transaminases in these Phase 1 studies and the ongoing Phase 2 study (NCT05579977)

The bioefficacy of an oral glutathione supplement formulation is determined by its bioavailability and absorption of the active ingredient in the body

However, no significant ROS accumulation (neither mitochondrial SOX nor cellular ROS) was detected upon BSO treatment ( Supplemental Figure 2B )