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As shown in Table 2, 22 proteins that demonstrated significantly different expression levels were identified by mass spectrometry coupled with genome-wide analysis of E

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To be clear, this data targets obese individuals medically defined as having a BMI of 35 to 39.9, with weight-related health issues or a BMI equal to or greater than 40

Similarly, in the human chondrocyte SW1353 cell line, dulaglutide inhibited AGEs-induced activation of NFkB and the expression of pro-inflammatory cytokines [99], whilst in human knee OA primary articular chondrocytes, lixisenatide reduced mRNA ad protein expression of TNF-, IL-6 and IL-7 [100]