PCs are present in multiple tissues, including brain and nerve, and can also act as an emulsifier in the lungs
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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted
On the other hand, the Danish Steno-2 study found that while intensive multifactorial intervention (targeting glucose, blood pressure, lipids and other risk factors) dramatically reduced cardiovascular events and mortality by approximately 50%, it showed no significant reduction in DPN (HR 1.12), suggesting that neuropathy may be more resistant to multifactorial interventions compared with other diabetic complications [62]