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Within the hypothalamus, brain CPT1C serves as a sensor of nutrient availability by binding malonyl-CoA which triggers a reduction in the release of the appetite promoting neuropeptides, neuropeptide Y (NPY) and Agouti-related peptide (AgRP) and an increase the release of the appetite suppressing neuropeptides, -melanocyte stimulating hormone (-MSH) and cocaine and amphetamine regulated transcript (CART)

An empty stomach combined with any subcutaneous injection can produce temporary queasiness in some individuals