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However, GLP-1 can activate GCGR in cells, and GCGR is able to reduce the number of docking granules by coupling and activating inhibitory GTP binding protein (Gi/o), thus inhibiting the secretion of glucagon, which is independent of GLP-1R (Gandasi et al., 2024)

GLP-1 was initially discovered for its ability to enhance glucose-stimulated insulin secretion (GSIS) (Kreymann et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

Conversely, anxiety, heat sensitivity, or rapid heartbeat might indicate levothyroxine excess

This does not exclude the possibility of skin sensitivity occurring in a subset of patients, particularly as Phase 3 trials enrol larger and more diverse populations