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SKU: 38374060851
4.4
USD20.40 USD65.40

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Ships within 48 hours · Estimated delivery Aug 30 - Sep 4

Description

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In LPS-induced neuroinflammation models, ALC confers neuroprotection by suppressing the TLR4/NFB pathway, restoring autophagy activity, and inhibiting oxidative stress.[13] ALC reduces microglial activation and release of inflammatory mediators by balancing pro-inflammatory and anti-inflammatory cytokines.[14][15] ALC attenuates microglial activation in a dose-dependent manner, with 100 mg/kg/day showing beneficial effects on LPS-induced neuroinflammation in mice, associated with increased brain-derived neurotrophic factor (BDNF) concentration.[14] In repetitive mild traumatic brain injury models, ALC treatment showed protective effects against neurodegeneration and inflammation, reducing mRNA levels of MAPT, TNF, and GFAP in the cortex.[16] Combination Strategies for Neuroinflammation: ALC 1,500-2,000 mg/day + PEA 1,200 mg/day (complementary anti-inflammatory mechanisms) + Omega-3 fatty acids 2-4 g/day (specialized pro-resolving mediator precursors) + Curcumin 500-1,000 mg/day (complementary NF-B modulation) 4

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