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The rate shows a clear dose-response pattern: in the SURMOUNT-1 trial published in the New England Journal of Medicine (N=2,539 adults followed for 72 weeks), reported rates climbed from roughly 12% at the 2.5 mg starting dose to 23% at the 15 mg top dose, compared to about 8% on placebo
Yet clarity about what its like to actually take these medications is in short supply
It encourages a continuous increase in growth hormone and IGF-1 levels
These mechanisms have made it a popular choice among people with type 2 diabetes and those struggling with obesity
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