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In the late 19th and early 20th centuries, investigators such as Sidney Ringer, who developed Ringers solution, Alexis Hartmann, who added lactate to create lactated Ringers (Hartmanns) solution, and Hartog Jakob Hamburger, whose work contributed to the adoption of 0.9% normal saline, progressively refined fluid composition into the crystalloid solutions used today

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IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division