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Typical Protocol: Injectable subcutaneous dosing generally runs 1-2mg per day, often started at 0.5-1mg for the first 1-2 weeks before increasing

Notably, the liver is a major target organ for the metabolic effects of insulin and exerts a first-pass extraction of up to 85% of insulin delivered by the portal vein (10)

For instance, a study by Grace et al., on lambs receiving a single 2 mg subcutaneous B12 injection demonstrated significant increases in serum and liver B12 concentrations for up to 24 days compared to untreated animals (2)

With compounded retatrutide, you need to: Calculate how much BAC water to add for your desired concentration Properly mix the solution without damaging the peptide Store the reconstituted solution correctly Calculate the right volume (in insulin units) for each dose Our free reconstitution calculator handles all the math for you