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Once the medication is stopped, appetite returns to pre-medication levels, and with that change, an increase in caloric intake. It can feel impossible to keep up with the lower calorie intake you might have maintained on a GLP-1 once your appetite and the food noise (a.k.a
in rodents it is described as unusually resistant to degradation Sikiric et al., 2025
Instead, it works slowly by signaling hormones that control appetite and blood sugar
Drug PAs account for a substantial fraction of PA workload
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