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Data from the ORION study, presented at the Obesity Medicine Associations 2026 annual conference, showed that oral semaglutide 25 mg was associated with significantly greater mean weight loss than orforglipron in a population-adjusted indirect treatment comparison
Second, the arginine at position 3 in the native sequence was substituted with leucine (hence R3)
The PGS weights used in this study are available in refs
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