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In the head-to-head comparison between tirzepatide and semaglutide, the two drugs yielded similar risks for component endpoints all-cause mortality (HR 1.03, 95% CI 0.84 to 1.27), myocardial infarction (HR 1.03, 95% CI 0.88 to 1.21) and stroke (HR 1.15, 95% CI 0.92 to 1.45) (Fig
However, these drugs also induce oxidative stress in cells, resulting in the induction of the expression of antioxidative transcription factors such as NRF2
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
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