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GLP-1 RAs could inhibit the expression of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) in human vascular endothelial cells in vitro, which had a protective effect against endothelial cell dysfunction (ECD) in the early stages of diabetic vascular disease [32] and might explain the lower incidence of background and severe nonproliferative DR among individuals who used GLP-1 RAs
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Apostolopoulos, Vitamin B1, B2, B3, B5, and B6 and the Immune System, in Nutrition and Immunity, Cham: Springer International Publishing, 2019, pp
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