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Introduction Fetal growth restriction (FGR) is a severe condition during pregnancy, where the fetus does not grow according to its potential as a result of an adverse uterine environment (Kingdom and Smith, However, the principal factor of cerebrovascular diseases is the BBB breakdown, characterized by blood component infiltration, aberrant transport, and clearance of molecules into the central nervous system (CNS) (Yang and Rosenberg, Figure 1)

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