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The specific mechanisms by which GLP-1 RAs could impact electrolyte balance will differ depending on the individual and may include direct effects, such as altering insulin levels and influencing sodium handling by the kidneys, or indirect effects, such as decreased food, fluid, and electrolyte intake, or gastrointestinal side effects like nausea and vomiting, Dr

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Because of their complementary modes of action, basal insulin and GLP-1RAs together act in most of the defects seen in T2DM, in accordance with its complex physiopathology (Fig