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Transdermal microneedles loaded with allopurinol achieve sustained urate-lowering effects by controlling drug release kinetics while minimizing gastrointestinal side effects observed with oral formulations ( 4 nanoflowers, coupled with hyaluronic acid microneedles, enhance enzyme stability and catalytic activity, effectively reducing serum uric acid levels by 30% in murine models ( Polymeric drug delivery systems (PDDS) offer transformative potential for gout and hyperuricemia through controlled release, targeted delivery, and multi-mechanistic synergies
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