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DPP-IV inhibitors, by virtue of their mechanism of action, increase the bioavailability of GLP-1 and GIP, leading to enhanced insulin secretion, improved glycemic control, and reduced insulin resistance in diabetes
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The trial was sponsored by Eli Lilly, which produces orforglipron and also makes the injectable GLP-1 drug tirzepatide under the brand names Mounjaro for type 2 diabetes and Zepbound for chronic weight loss
Carbohydrates help drive that activity
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