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To determine if the observed effects of liraglutide to increase bihormonal insulin + glucagon + cells are mediated by the cell GLP-1R, we assessed the effect of liraglutide treatment on insulin and glucagon coexpression in our cell GLP-1RKO mouse line
Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (Getgoal-X)
Therefore, GLP-1-induced Nfr2 activation could be relevant to GLP-1-induced autophagy, but further study is needed
In some cases, significant weight loss and energy deficit can lead to functional hypothalamic amenorrhoea, where the brain temporarily reduces signals to the ovaries
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