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Description

Its biosynthesis is catalyzed by sphingomyelinase, a phosphodiesterase that hydrolyzes the membrane sphingolipid sphingomyelin (SM) to generate ceramide (Zeidan and Hannun, 2010)

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33 Interestingly, many clinical studies have demonstrated that the administration of GLP-1 RAs produces a rapid, substantial and dose-dependent reduction in epicardial adipose tissue thickness

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