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In a Chinese phase II clinical trial, mazdutide decreased HbA1c by 1.41% to 1.67% in a dose-dependent manner, while a placebo decreased HbA1c by + 0.03% [102]
doi: 10.1016/j.cotox.2017.11.002, 71
Reactive nitrogen species arise primarily from the metabolism of nitric oxide (NO), a signalling molecule synthesized from arginine by nitric oxide synthases [29]
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