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Furthermore, FMO3 has been shown to serve as a central regulator of tissue cholesterol balance and to be involved in insulin resistance and dyslipidemic changes in mouse models, suggesting the FMO3 and TMAO pathway as potential mediators of diabetes associated atherosclerosis 52,53
While most patients tolerate the medication well, some individuals report skin changes, including itching, during their treatment journey
was funded by the PRIME JP17gm5910013 and the LEAP JP17gm0010004 from the Japan Agency for Medical Research and Development, and JSPS KAKENHI 17K08264
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