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As a widely used antihypertensive drug, losartan enhances vascular perfusion, thereby enhancing drug delivery and intratumoral invasion of immune effector cells and, on the other hand, enhances chemotherapy sensitivity by inhibiting IGF-1 signaling to reshape ovarian cancer and the microenvironment (140)

Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP

Adherence to Consolidated Standards of Reporting Trials (CONSORT) guidelines for reporting safety outcomes in trials of medical cannabis and cannabis-based medicines for chronic noncancer pain: a systematic review

Clinical-pharmacology reviews describe how the MC1R-preferential mechanism translates into a measurable rise in melanin density and photoprotection, and how the slow-release implant delivers the peptide over weeks rather than as a short injectable pulse