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Both effects are a direct result of MT2 binding to different melanocortin receptors (MC1R for tanning, MC4R for appetite)
However, the fact that discontinuation rates remained low suggests that most patients can tolerate the side effects with proper dose escalation and management
Symptoms consist of profuse bloody diarrhea (occurring six or more times per day), often with a sustained fever and tachycardia (rapid heart rate)
reported reduction of body weight, HbA1c levels and blood pressure after 6-month treatment with sitagliptin [135]
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