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This triple-hormone receptor activation is thought to enhance the medications efficacy in promoting weight loss by targeting multiple pathways involved in energy balance and appetite regulation
A real-world study followed individuals who started GLP-1 medications and discontinued them within 3 to 12 months to assess weight changes after stopping treatment
However, the relative contributions of GIP and GLP-1 to the incretin effect and glycemic control under physiological and pharmacological conditions remain a topic of debate
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
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