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Notably, disruption of protein homeostasis is not only a direct consequence of heat stress but also an important trigger for the activation of the HSP system (Rutledge et al., 2022

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B-Together is a phase 2b trial (NCT04676724) assessing the efficacy and safety of sequential treatment of up to 24 wk BPV followed by up to 24 wk of pegylated interferon (PegIFN) in patients with CHB