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Not all drugs need to reach the systemic circulation to exert their effects, for example, oral vancomycin used to treat pseudomembranous colitis

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Horm Metab Res 11:655658, 1977 Baxter JN, Jenkens SA, Day DW, Roberts DC, Cowelt DC, Mackie CR, Shields R: Effects of somatostatin and a long-acting somatostatin analogue on the prevention and treatment of experimentally induced acute pancreatitis in rat

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BPC-157 acts as an analgesic and promotes faster healing of skin burns by enhancing blood flow to damaged tissues

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