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doi:10.1038/nn0507-535
A systematic review in 2024 identified 36 studies (35 preclinical, 1 clinical) from 1993 to 2024
Laser Therapy Creams can reduce symptoms, but they rarely remove visible vessels
Red Flags to Avoid No COA available, or a COA that won't load / is image-only with no lab name Batch numbers that don't match between COA and vial Purity claimed with no supporting HPLC chromatogram Marketing that presents the retracted "seven orders of magnitude more potent than BDNF" figure as settled fact (see the evidence section below) Human dosing instructions or therapeutic claims on the listing a tell that the seller is ignoring RUO rules Vendor copy citing a "12.8-day half-life" as established this figure appears only in vendor marketing, with no verifiable peer-reviewed source A clean COA verifies that the powder is what the label says
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