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(Lyons et al., 2016) further observed that SSRIs such as fluoxetine and sertraline inhibit the activity of dopaminergic neurons in neuroendocrine leaky nodules through the activation of G protein-coupled inwardly rectifying K + -like currents mediated by the 5-hydroxytryptamine 1A receptor, leading to reduced intrinsic excitability and slower tuberoinfundibular dopamine (TIDA) network rhythms, thereby increasing prolactin secretion

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