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SKU: 37700510141

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It remains uncertain whether distinct initiation mechanisms trigger the inflammatory response by acting on priming signaling pathways, or if a reduction in the negative regulation of NLRP3 activation amplifies the inflammatory cascade

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Haverty T, Wyatt DJ, Porter KM, Leubitz A, Banks K, Goodyer P, Hu MY (2021) Phase 1 renal impairment trial results supports targeted individualized dosing of ELX-02 in patients with nephropathic cystinosis