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Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S (2016) Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and Meta-analysis

15 demonstrating powerful inhibition of food intake after ICV administration of GLP-1, an effect that could be blocked by the specific receptor antagonists exendin 939, which also enhanced spontaneous as well as neuropeptide Y-stimulated food intake

Some have additional proven benefits, such as protecting the heart or kidneys or treating obstructive sleep apnea

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