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Obesity and metabolic disease carry particular health burdens for men, including increased risk of type 2 diabetes, cardiovascular disease, obstructive sleep apnoea, and hypogonadism (low testosterone)
Women tend to experience more gastrointestinal side effects at each dose level in clinical trial data, though the difference is not large enough to warrant a different escalation schedule
Still, thats not to say that C ratings are completely garbage
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