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The most common adverse events reported with oral semaglutide were mild-to-moderate transient gastrointestinal eventsa finding consistent with the known tolerability of other available GLP-1 receptor agonists
A series of 10 phase 3 multicenter, randomized clinical studies as part of the Peptide InnOvatioN for Early diabetes tReatment (PIONEER) program were conducted to compare the efficacy and safety of oral semaglutide with either placebo or active comparators [2131]
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