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Your body has reduced NEAT (non-exercise activity thermogenesis) by 200400 calories/day in response to the caloric deficit
ROS also induce the release of Ca 2+ by activating inositol 1,4,5-trisphosphate receptors (IP3R) to open the permeability transition pore, thereby changing the permeability of mitochondria to further release more ROS as a vicious cycle (Csordas and Hajnoczky, 2009
Long term, however, weight loss and GLP-1s may reduce flare frequency
Tendon, ligament, and joint stress modeling
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