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The analysis of the optimized structures of the MichaelisMenten complex indicate that the polar residues at position 13 (Cys or Ser) stabilize the deprotonated GS , which in turn acts as the catalytic Brnsted base and abstracts the proton at position C2 of substrate 7 (Extended Data Fig

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Remodelacin de la matriz extracelular: El GHK-Cu modula la expresin de ms de 4000 genes, muchos de los cuales estn implicados en la remodelacin tisular, la respuesta al estrs y la apoptosis