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By raising intragastric pH, G-Omeprazole 40 mg/vial can significantly alter the absorption of drugs whose solubility depends on gastric acidity: Because G-Omeprazole 40 mg/vial is metabolized by and can inhibit CYP2C19, co-administration may delay the elimination of the following drugs, potentially increasing their plasma levels and risk of adverse effects: Concomitant administration of G-Omeprazole 40 mg/vial and Clarithromycin results in mutually increased plasma concentrations of both drugs
analyzed 272 samples and found a significantly higher -AASA/creatinine ratio in this group of patients with a significant age dependency [24]
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