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We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro
This quickly boosts vitamin B12 levels in those who are low
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For someone who hasn't responded adequately to supplements, DSIP represents a more potent intervention
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