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In an experimental study performed in 5/6 nephrectomized normo- and hyperuricemic rats, febuxostat protected against renal damage, and prevented proteinuria, preserving vessel morphology and glomerular pressure, thus it prevents progression of CKD independently of its effect on UA.46 In the FOCUS47 extension study, 116 patients treated with febuxostat were followed for 5 years
Es el tratamiento inicial en todos los casos, incluso cuando est indicada la exanguinotransfusin, mientras se prepara para esta (8)
At the same time, we also have to acknowledge that many of these compounds still lack large-scale human clinical trials and long-term safety data
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