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Individuals with T21 are known to exhibit an increased risk of impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction, which collectively contribute to altered energy utilization and elevated cardiometabolic risk 53,54
Elmslie, J
( Dipsas dendrophila , new species, p
However, gastrointestinal side effects and loss of lean mass are notable concerns ( Lifestyle interventions, including exercise and dietary modification, remain the cornerstone of obesity and diabetes management, with proven benefits for weight loss, glycemic control, cardiovascular health, and quality of life (30)
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