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Regarding indication for GLP-1 RA use in reports in the study, possible off-label use was identified as the main reason for prescription, followed by weight management and diabetes
Pregnant or breastfeeding women, individuals with a personal or family history of medullary thyroid carcinoma, or those with certain gastrointestinal conditions are typically not eligible
A recent 2025 report in JAMA ophthalmology, has also found that patients with longer durations of exposure to GLP-1 agonists were associated with a higher risk of developing neovascular age-related macular degeneration
This is less common, requires two syringes per dose, and is mostly used when the vial has a thick rubber stopper that dulls the needle on the draw
