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Possible dose-dependent fatigue or lethargy

Prior weight loss drugs were unpleasant (rimonabant), ineffective (Contrave), or dangerous (methamphetamine, fen-phen, 2,4-DNP)

Before the kidneys show up in the labs

Accordingly, we found that artificial elevation of glutathione levels may induce SA accumulation in tobacco leaves, either following a single infiltration of exogenous GSH or OTC or continuous exposure to OTC ( Figure 1B , Figures S1 and S2 ) Furthermore, although GSH and OTC treatments of SA-deficient NahG tobacco did not increase free SA levels, bound SA levels were unexpectedly (1.5 to 2-fold) higher in treated NahG plants