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The clinical translation of nanomedicines for melanoma faces multiple challenges, including scalability and manufacturing complexities (e.g., difficulties in large-scale production of biomimetic nanoparticles under GMP standards), safety and immunogenicity concerns (such as unintended immune responses and limited long-term toxicity data), and biological barriers like tumor heterogeneity and the immunosuppressive TME
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Protein Data Bank in Europe, National Center for Biotechnology Information (2023)
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