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Higher doses of dulaglutide (3.0 mg and 4.5 mg) [29] have also received marketing approval for treatment of type 2 diabetes, while application for a label extension of semaglutide at the dose of 2.0 mg [30] has been submitted to the US FDA and has recently received a positive recommendation by the EMA

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Posttranscriptional aspects of polyamine-mediated gene regulation are associated with the eukaryotic translation initiation factor 5A (eIF5A), whose expression/function is strongly correlated with unfavorable prognostic implications for several cancers 73,74,75