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Not all patients with excess fat mass develop T2D (although many have prediabetes) because the level at which adiposopathy is established is variable and based on various factors including central (visceral) vs peripheral (subcutaneous) distribution, sexual dimorphism, adipocyte endowment in childhood, and intrauterine and neonatal epigenetic imprinting as that observed in neonates with low and high birth weight who are both at increased risk of obesity and T2D [14, 15]

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Using a test in which trial volunteers were offered their preferred beverage to drink over two hours, the study found that people who received semaglutide drank about 50% less than the people given placebo at the end of the eight-week treatment period, as measured by breath alcohol concentration and grams of alcohol consumed