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542 The Phase III trial Lp(a)-HORIZON is underway, involving 8,323 patients with established ASCVD, and is expected to be completed in 2025 (NCT04023552)
Gastrointestinal symptoms have also been reported, including heartburn, abdominal pain, belching, nausea, vomiting, flatulence, constipation, and diarrhea (106)
The FDA has approved semaglutide for the treatment of type 2 diabetes and for weight management at standard doses
Last but not least, GSH participates in non-enzymatic conjugation with some chemicals, for instance, it is hypothesized that glutathione reacts with n-acetyl-p-benzoquinone imine (NAPQI) -the cytochrome P450 reactive metabolite formed by toxic overdose of acetaminophen- to detoxify it.
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