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These compounded versions include modified formulations and added ingredients, and some versions are manufactured outside regulated supply chains, making their genetic makeup significantly different from approved registered products." Green notes that the safety alarm has been loudest in the United States: "The notice from the FDA has raised significant safety concerns, including dosing errors and the circulation of active ingredients sourced from unregistered facilities." South Africa, he warns, is increasingly in the crosshairs: "While the South African Health Products Regulatory Authority (SAHPRA) has publicly raised concerns on the issue and moved to declare compounded GLP-1's undesirable under section 23 of the Medicines Act, the declaration has not yet been made

Table 3 Comparison of serum concentrations of LC (g/mL) and ALC (g/mL) before and after treatment (mean SD)

Some meal delivery services already cater to these dietary needs with a GLP-1-specific menu, particularly in their prepared-food options

When should I contact a healthcare provider about injection site reactions